(四氢吡喃-4-基)甲基甲苯磺酸合成路线 （共 6 条）
反应条件
in 2-methyl tetrahydrofuran; water T=35°C; Cooling;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BERRY, Angela; RIETHER, Doris; ERMANN, Monika; JENKINS, James Edward; MUSHI, Innocent
Patent: WO2011/88015 A1, 2011 ;
Location in patent: Page/Page column 38-39 ;
WO 2011/088015 A1
反应条件
1: 3,4,5,6-Tetrahydro-2H-pyran-4-carboxylic acid With borane-THF in tetrahydrofuran T=20°C; 6 h; 2: p-toluenesulfonyl chloride in pyridine; dichloromethane
参考文献
WO2003/101959 A1, ;
Page 248-249 ;
WO 03/101959 A1
反应条件
1: LiAlH4 / diethyl ether / 3 h / Heating 2: pyridine / 1.) 5 deg C, 2 h, 2.) RT, 1 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 115, # 18 p. 8401 - 8408
反应条件
1: K2CO3 / acetone / 3 h / Heating 2: LiAlH4 / diethyl ether / 3 h / Heating 3: pyridine / 1.) 5 deg C, 2 h, 2.) RT, 1 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 115, # 18 p. 8401 - 8408
反应条件
sodium iodide in acetone T=60°C; 16 h;
参考文献
Corbett, Wendy Lea; Grimsby, Joseph Samuel; Haynes, Nancy-Ellen; Kester, Robert Francis; Mahaney, Paige Erin; Racha, Jagdish Kumar; Sarabu, Ramakanth; Wang, Ka
Patent: US2003/225283 A1, 2003 ;
Location in patent: Page 26-27 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium bromide 5 h; Heating; Yield given;
参考文献
Radziszewski, Juliusz G.; Kaszynski, Piotr; Littmann, Dieter; Balaji; Hess Jr.; Michl, Josef
Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8401 - 8408
