in dimethyl sulfoxide T=140°C; 0.5 h;

1: dimethylformamide / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 78 percent / pyridine / CH2Cl2 / 50 °C 7: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 78 percent / pyridine / CH2Cl2 / 50 °C 6: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: toluene / 1 h / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 78 percent / pyridine / CH2Cl2 / 50 °C 7: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 2: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 3: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 4: 78 percent / pyridine / CH2Cl2 / 50 °C 5: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: 78 percent / pyridine / CH2Cl2 / 50 °C 2: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 78 percent / pyridine / CH2Cl2 / 50 °C 3: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

pseudomonas fluorescens lipase in chloroform T=20°C; 72 h; Title compound not separated from byproducts;

1: tetrabutylammonium bromide; potassium hydroxide / 18 h / 35 - 40 °C 2: 903 mg / p-toluenesulfonic acid / tetrahydrofuran; H2O / Heating 3: Pseudomonas fluorescens lipase / CHCl3 / 72 h / 20 °C View Scheme

1: 903 mg / p-toluenesulfonic acid / tetrahydrofuran; H2O / Heating 2: Pseudomonas fluorescens lipase / CHCl3 / 72 h / 20 °C View Scheme