5,8-二甲氧基-1-四氢萘酮合成路线 （共 21 条）
反应条件
PPA T=80°C; cyclocondensation; 0.5 h;
参考文献
Wipf, Peter; Jung, Jae-Kyu
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6319 - 6337
反应条件
in toluene T=110°C; 48 h;
参考文献
Hickman, Derek N.; Hodgetts, Kevin J.; Mackman, Peter S.; Wallace, Timothy W.; Wardleworth, J. Michael
Tetrahedron, 1996 , vol. 52, # 6 p. 2235 - 2260
反应条件
1: Zn; HCl / 3-methyl-butan-1-ol 2: PPA View Scheme
参考文献
Wu, Xihan; Xu, Liang; Cai, Junchao
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 18 p. 2635 - 2638
反应条件
1: Zn; HCl / 3-methyl-butan-1-ol 2: PPA View Scheme
参考文献
Yang, Zhen; Cui, Yu Xin; Wong, Henry N. C.; Wang, Ru Ji; Mak, Thomas C. W.; et al.
Tetrahedron, 1992 , vol. 48, # 16 p. 3293 - 3302
反应条件
1: 91 percent / H2 / 10percent Pd/C / ethanol / 0.33 h 2: 72 percent / polyphosphoric acid / 0.5 h / 85 °C View Scheme
参考文献
Salley, John J.; Glennon, Richard A.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 545 - 550
反应条件
1: 82 percent / NaH / dimethylsulfoxide; tetrahydrofuran / 1. 0 deg C, 2. room temp., 15 h. 2: 91 percent / H2 / 10percent Pd/C / ethanol / 0.33 h 3: 72 percent / polyphosphoric acid / 0.5 h / 85 °C View Scheme
参考文献
Salley, John J.; Glennon, Richard A.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 545 - 550
反应条件
1: 88 percent / tetrahydrofuran / 1.5 h / -10 °C 2: 90 percent / toluene / 56 h / Heating View Scheme
参考文献
Hickman, Derek N.; Wallace, Timothy W.; Wardleworth, J. Michael
Tetrahedron Letters, 1991 , vol. 32, # 6 p. 819 - 822
反应条件
1: NaBH4 / ethanol / 12 h / Ambient temperature 2: p-toluenesulfonic acid monohydrate / benzene / 0.5 h / Heating 3: m-chloroperbenzoic acid / CH2Cl2 / 12 h / 0 °C 4: p-toluenesulfonic acid monohydrate / toluene / 1.5 h / Heating View Scheme
参考文献
Perez; Rosell; Mauleon; Carganico
Farmaco, 1991 , vol. 46, # 10 p. 1155 - 1166
反应条件
formic acid; potassium iodide T=105°C;
参考文献
Warrener, Ronald N.; Gee, Paul S.; Russell, Richard A.
Journal of the Chemical Society, Chemical Communications, 1981 , # 21 p. 1100 - 1101
反应条件
1.1: NaBH4
1.2: ceric ammonium nitrate
2.1: LiOt-Bu / tetrahydrofuran / 0.42 h / -60 °C
2.2: 46 percent / tetrahydrofuran / -60 - 20 °C
View Scheme
参考文献
Mal, Dipakranjan; Ray, Sutapa; Sharma, Indrajeet
Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 4981 - 4984
