2-溴-4,6-二氟苯胺氢溴酸合成路线 （共 7 条）
反应条件
bromine in acetic acid 0.25 h; Ambient temperature;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h 2: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating 3: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating View Scheme
参考文献
Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Frazee, James S.; Erickson, Robert W.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 887 - 889
反应条件
sodium nitrite in hydrogenchloride
参考文献
Mallinckrodt Specialty Chemicals Company
Patent: US5157169 A1, 1992 ;
反应条件
sodium hypophosphite; hydrogen bromide; sodium nitrite Yield given. Multistep reaction;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h 2: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating 3: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating 4: 66 percent / pyridine, piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h 5: 97 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h 2: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating 3: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating 4: 66 percent / pyridine, piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 3 p. 486 - 494
反应条件
1: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h 2: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating View Scheme
参考文献
Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Frazee, James S.; Erickson, Robert W.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 887 - 889
