(-)-(6-丙基氨基)-5,6,7,8-四氢-萘-1-醇合成路线 （共 15 条）
反应条件
sodium hydrogencarbonate in acetonitrile 9 h; Reflux;
参考文献
WO2010/43571 A1, ;
Page/Page column 9 ;
反应条件
sodium carbonate in anhydrous xylene T=140°C; 24 h;
参考文献
Organic Letters, , vol. 12, # 23 p. 5418 - 5421
反应条件
1: thiophen-2-yl-acetic acid With sodium tetrahydroborate in toluene T=20 - 25°C; 1 h; Inert atmosphere; 2: Desthienyl-Rotigotine in toluene T=80 - 90°C; 8 h; Inert atmosphere;
参考文献
US2011/230541 A1, ;
Page/Page column 3 ;
反应条件
sodium hydrogencarbonate in acetonitrile 9 h; Reflux;
参考文献
WO2013/168033 A1, ;
Paragraph 00108 ;
反应条件
in 2-methylpropyl acetate T=110°C; 10 h; Product distribution / selectivity;
参考文献
WO2009/53697 A1, ;
Page/Page column 14; 15 ;
反应条件
potassium carbonate in toluene
T=60°C;
参考文献
Marquillas Olondriz, Francisco; Pomares Marco, Marta
Patent: US2011/152543 A1, 2011 ;
Location in patent: Page/Page column 3; 4 ;
反应条件
1: With boron tribromide in dichloromethane
T=-40 - 20°C;
2: With water; sodium hydrogencarbonate in dichloromethane
参考文献
Webster, Robert; Boyer, Alistair; Fleming, Matthew J.; Lautens, Mark
Organic Letters, 2010 , vol. 12, # 23 p. 5418 - 5421
反应条件
1: 99 percent / K2CO3 / butan-2-one / 30 h / 90 °C
2: 84 percent / H2, AcOH / 10percent Pd/C / ethanol / Ambient temperature
3: 61 percent / 48percent HBr / 15 h / 130 °C
View Scheme
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
反应条件
1: 84 percent / H2, AcOH / 10percent Pd/C / ethanol / Ambient temperature
2: 61 percent / 48percent HBr / 15 h / 130 °C
View Scheme
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
反应条件
sodium hydroxide; water in dichloromethane
0.5 h; Product distribution / selectivity;
参考文献
PLIVA HRVATSKA D.O.O.; BUCKS, Teresa Anne
Patent: WO2009/53697 A1, 2009 ;
Location in patent: Page/Page column 15 ;
