4-(苯基甲基氨基羰基)哌啶合成路线 （共 8 条）
反应条件
trifluoroacetic acid T=20°C; 24 h;
参考文献
Sams, Anette G.; Hentzer, Morten; Mikkelsen, Gitte K.; Larsen, Krestian; Bundgaard, Christoffer; Plath, Niels; Christoffersen, Claus T.; Bang-Andersen, Benny
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6386 - 6397
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2.5 h;
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
反应条件
in dimethyl sulfoxide
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US5723490 A1, 1998 ;
US 5723490 A
反应条件
methanol; platinum Hydrogenation;
参考文献
Swain; Naegele
Journal of the American Chemical Society, 1957 , vol. 79, p. 5250,5252
反应条件
1: 87 percent / triethylamine / tetrahydrofuran; H2O / 20 °C 2: 93 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C 3: TFA / CH2Cl2 / 2.5 h / 20 °C View Scheme
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
反应条件
1: 93 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C 2: TFA / CH2Cl2 / 2.5 h / 20 °C View Scheme
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C 2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C View Scheme
参考文献
Hu, Suwen; Gu, Quan; Wang, Zhilong; Weng, Zhiyong; Cai, Yunrui; Dong, Xiaowu; Hu, Yongzhou; Liu, Tao; Xie, Xin
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 259 - 266
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C 2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C View Scheme
参考文献
Hu, Suwen; Gu, Quan; Wang, Zhilong; Weng, Zhiyong; Cai, Yunrui; Dong, Xiaowu; Hu, Yongzhou; Liu, Tao; Xie, Xin
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 259 - 266
