2-(2-苯氧基乙氧基)-苯甲酸合成路线 （共 5 条）
反应条件
1: With water; sodium hydroxide in methanol T=60°C; 3.5 h; 2: With hydrogenchloride in water Product distribution / selectivity;
参考文献
KAKEN PHARMACEUTICAL CO., LTD.
Patent: EP2168951 A1, 2010 ;
Location in patent: Page/Page column 42; 75 ;
反应条件
1: 88 percent / K2CO3 / dimethylformamide / 96 h / Ambient temperature 2: 98 percent / 1N aq. NaOH / CH2Cl2 / 1.) RT, 90 min, 2.) reflux, 12 h View Scheme
参考文献
Thaisrivongs; Turner; Strohbach; TenBrink; Tarpley; McQuade; Heinrikson; Tomasselli; Hui; Howe
Journal of Medicinal Chemistry, 1993 , vol. 36, # 8 p. 941 - 952
反应条件
1: 88 percent / K2CO3 / dimethylformamide / 96 h / Ambient temperature 2: 98 percent / 1N aq. NaOH / CH2Cl2 / 1.) RT, 90 min, 2.) reflux, 12 h View Scheme
参考文献
Thaisrivongs; Turner; Strohbach; TenBrink; Tarpley; McQuade; Heinrikson; Tomasselli; Hui; Howe
Journal of Medicinal Chemistry, 1993 , vol. 36, # 8 p. 941 - 952
反应条件
1,4-dioxane; potassium carbonate Erhitzen des Reaktionsprodukts mit wss. NaOH;
参考文献
Bost; Winstead
Journal of the American Chemical Society, 1952 , vol. 74, p. 1821,1823
反应条件
n-butyllithium; diethyl ether
参考文献
Oita; Gilman
Journal of Organic Chemistry, 1956 , vol. 21, p. 1009,1011
