(2E)-n-(2-溴苯基)-2-(羟基亚氨基)乙酰胺合成路线 （共 10 条）
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in water T=35 - 85°C; 3 h;
参考文献
Matesic, Lidia; Locke, Julie M.; Vine, Kara L.; Ranson, Marie; Bremner, John B.; Skropeta, Danielle
Tetrahedron, 2012 , vol. 68, # 34 p. 6810 - 6819
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate Heating;
参考文献
DECODE CHEMISTRY, INC.
Patent: WO2006/44415 A2, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/044415 A2
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in water T=90°C; 3 h;
参考文献
ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; THOMPSON, Scott, Kevin; HOSAHALLI, Subramanya; BEJUGAM, Mallesham; NANDURI, Srinivas; PANIGRAHI, Sunil, Kumar; MAHALINGAM, Natarajan
Patent: WO2012/58671 A1, 2012 ;
Location in patent: Page/Page column 105-106 ;
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate T=37 - 45°C; 4.5 h;
参考文献
Cheung, Chi-Ming; Goldberg, Frederick W.; Magnus, Philip; Russell, Claire J.; Tumbull, Rachel; Lynch, Vince
Journal of the American Chemical Society, 2007 , vol. 129, # 40 p. 12320 - 12327
反应条件
hydroxylamine hydrochloride in water T=40 - 75°C; 4 h;
参考文献
Wang, Jianguo; Tan, Haizhong; Li, Yonghong; Ma, Yi; Li, Zhengming; Guddat, Luke W.
Journal of Agricultural and Food Chemistry, 2011 , vol. 59, # 18 p. 9892 - 9900
反应条件
1: hydrogenchloride; sodium sulfate / water / 0.9 h / 40 °C 2: hydroxylamine hydrochloride / water / 4 h / 40 - 75 °C View Scheme
参考文献
Wang, Jianguo; Tan, Haizhong; Li, Yonghong; Ma, Yi; Li, Zhengming; Guddat, Luke W.
Journal of Agricultural and Food Chemistry, 2011 , vol. 59, # 18 p. 9892 - 9900
参考文献
Pergola, Carlo; Gaboriaud-Kolar, Nicolas; Jestaedt, Nadine; Koenig, Stefanie; Kritsanida, Marina; Schaible, Anja M.; Li, Haokun; Garscha, Ulrike; Weinigel, Christina; Barz, Dagmar; Albring, Kai F.; Huber, Otmar; Skaltsounis, Alexios L.; Werz, Oliver
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3715 - 3723
反应条件
1: sulfuric acid 2: aqueous NaOH; aqueous H2O2 View Scheme
参考文献
Liu, Kevin K.C.; Huang, Xiaojun; Bagrodia, Shubha; Chen, Jeffrey H.; Greasley, Samantha; Cheng, Hengmiao; Sun, Shaoxian; Knighton, Dan; Rodgers, Caroline; Rafidi, Kristina; Zou, Aihua; Xiao, Jiezhan; Yan, Shengyong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1270 - 1274
反应条件
1.1: sulfuric acid / 1 h / 60 - 80 °C 2.1: sodium hydroxide; water; dihydrogen peroxide / 0.5 h / 50 °C 2.2: pH 4 3.1: tetrahydrofuran / 0.5 h / 0 - 20 °C View Scheme
反应条件
sulfuric acid T=90°C; 3 h;
参考文献
ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; THOMPSON, Scott, Kevin; HOSAHALLI, Subramanya; BEJUGAM, Mallesham; NANDURI, Srinivas; PANIGRAHI, Sunil, Kumar; MAHALINGAM, Natarajan
Patent: WO2012/58671 A1, 2012 ;
Location in patent: Page/Page column 106 ;
