5-氨基-1,3-二甲基-1H-吡唑-4-甲酰胺合成路线 （共 3 条）
反应条件
sodium hydroxide; water; dihydrogen peroxide in methanol T=20°C; 3 h;
参考文献
GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG
Patent: WO2009/97446 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/097446 A1
反应条件
1: 84 percent / ethanol / 2 h / Heating 2: 80 percent / conc. H2SO4 / 2 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 8 p. 1635 - 1644
反应条件
T=180°C; 4 h; Neat (no solvent);
参考文献
GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG
Patent: WO2009/97446 A1, 2009 ;
Location in patent: Page/Page column 65; 66 ;
WO 2009/097446 A1
