1: 69 percent / KOH / ethanol; H2O / 0.75 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -23 deg C, 2 h, 2.) THF, hexane, -23 deg C, 3 h 3: NH3 / tetrahydrofuran; hexane / 0.25 h / 5 °C 4: 1.) O3, 2.) H2O2 / 1.) Me2CO, water, 5 deg C, 30 min, 2.) Me2CO, water, 20 deg C, overnight View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -23 deg C, 2 h, 2.) THF, hexane, -23 deg C, 3 h 2: NH3 / tetrahydrofuran; hexane / 0.25 h / 5 °C 3: 1.) O3, 2.) H2O2 / 1.) Me2CO, water, 5 deg C, 30 min, 2.) Me2CO, water, 20 deg C, overnight View Scheme

1: 50 percent / acetic acid 2: 69 percent / KOH / ethanol; H2O / 0.75 h / Heating 3: 1.) n-BuLi / 1.) THF, hexane, -23 deg C, 2 h, 2.) THF, hexane, -23 deg C, 3 h 4: NH3 / tetrahydrofuran; hexane / 0.25 h / 5 °C 5: 1.) O3, 2.) H2O2 / 1.) Me2CO, water, 5 deg C, 30 min, 2.) Me2CO, water, 20 deg C, overnight View Scheme

dihydrogen peroxide; ozone 1.) Me2CO, water, 5 deg C, 30 min, 2.) Me2CO, water, 20 deg C, overnight; Yield given. Multistep reaction;

lutidine in dimethylsulfoxide-d6 T=37°C; other phenylketophosphoramides;

lutidine in dimethylsulfoxide-d6 T=37°C; other phenylketophosphoramides;