tert.-butylhydroperoxide; disodium tetrachloropalladate(II) trihydrate; sodium acetate in water; acetic acid; tert-butyl alcohol T=70°C; Wacker-Cook oxidation; 4 h;

sulfuric acid; nitric acid 3 h; Ambient temperature;

1: KOH 2: Br2 / pyridine 3: pyridine View Scheme

1: KOH 2: Br2 / pyridine 3: pyridine View Scheme

1: H2SO4, glacial acetic acid / 1 h / 95 - 100 °C 2: 91 percent / nitric acid, conc. sulfuric acid / 3 h / Ambient temperature View Scheme

1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, 078 deg C, 2 h, 2.) THF, a) -78 deg C, 1 h, b) RT, 20 h 2: H2SO4, glacial acetic acid / 1 h / 95 - 100 °C 3: 91 percent / nitric acid, conc. sulfuric acid / 3 h / Ambient temperature View Scheme

1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, 078 deg C, 2 h, 2.) THF, a) -78 deg C, 1 h, b) RT, 20 h 2: H2SO4, glacial acetic acid / 1 h / 95 - 100 °C 3: 91 percent / nitric acid, conc. sulfuric acid / 3 h / Ambient temperature View Scheme