1-甲基-1H-吡唑-3,5-二羧酸二乙酯合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C;
参考文献
Ghosh, Arun K.; Lei, Hui; Devasamudram, Thippeswamy; Tang, Jordan J. N.; Bilcer, Geoffrey; Liu, Chungfeng
Patent: US2008/125467 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
potassium carbonate in acetone Heating;
参考文献
Iturrino; Navarro; Rodriguez-Franco; Contreras; Escario; Martinez; Del Rosario Pardo
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 5 p. 445 - 451
反应条件
1: 93 percent / bromine 2: 94 percent / potassium carbonate / acetone / Heating View Scheme
参考文献
Iturrino; Navarro; Rodriguez-Franco; Contreras; Escario; Martinez; Del Rosario Pardo
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 5 p. 445 - 451
反应条件
1: 95 percent 2: 93 percent / bromine 3: 94 percent / potassium carbonate / acetone / Heating View Scheme
参考文献
Iturrino; Navarro; Rodriguez-Franco; Contreras; Escario; Martinez; Del Rosario Pardo
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 5 p. 445 - 451
反应条件
1: With sodium hydride in tetrahydrofuran T=0 - 20°C; 2: With methanol; potassium hydroxide T=20°C; 24 h; 3: With hydrogenchloride; lithium aluminium tetrahydride more than 3 stages;
参考文献
WO2006/34277 A1, ;
Page/Page column 60-61 ;
WO 2006/034277 A1
反应条件
1: With methanol; potassium hydroxide T=20°C; 24 h; 2: With hydrogenchloride; water 3: With lithium aluminium tetrahydride more than 3 stages;
参考文献
Ghosh, Arun K.; Lei, Hui; Devasamudram, Thippeswamy; Tang, Jordan J. N.; Bilcer, Geoffrey; Liu, Chungfeng
Patent: US2008/125467 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 88 percent / 6N HCl / H2O / 4 h / Heating
2: thionyl chloride / 1 h / Heating
View Scheme
参考文献
Elguero, J.; Navarro, P.; Franco, M. I. Rodriguez
Chemistry Letters, 1984 , p. 425 - 428
