2-甲氧基-4-甲基吡啶合成路线 （共 17 条）
反应条件
silver carbonate in dichloromethane
参考文献
Brodney, Michael A.; Padwa, Albert
Tetrahedron Letters, 1997 , vol. 38, # 35 p. 6153 - 6156
反应条件
1: 4-methyl-pyridin-2-ylamine With hydrogenchloride in methanol T=10 - 30°C; 1.5 h; 2: nitrous acid methyl ester in methanol T=20 - 30°C; 13 h; 3: With sodium hydroxide in water T=30°C; pH=12;
参考文献
EP1679003 A1, ;
Page/Page column 20-21 ;
反应条件
in methanol Heating;
参考文献
Adger, Brian M.; Ayrey, Peter; Bannister, Robin; Forth, Michael A.; Hajikarimian, Yousef; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2791 - 2796
反应条件
hydrogen bromide; bromine; sodium nitrite und Erwaermen des Reaktionsprodukts mit Natriummethylat in tert-Butylalkohol;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3160,3164
反应条件
in N,N-dimethyl-formamide T=100°C;
参考文献
Adger, Brian M.; Ayrey, Peter; Bannister, Robin; Forth, Michael A.; Hajikarimian, Yousef; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2791 - 2796
反应条件
T=50 - 70°C; 6 h; Heating / reflux;
参考文献
EP1679003 A1, ;
Page/Page column 21 ;
反应条件
1: 74 percent / phosphorus oxychloride / 2 h / 90 °C 2: 90 percent / methanol / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2791 - 2796
反应条件
1: 2-methoxy-4-picoline With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 1.5 h; 2: p-formaldehyde in tetrahydrofuran; hexane T=20°C; 8 h;
参考文献
GEORGETOWN UNIVERSITY
Patent: WO2005/806 A2, 2005 ;
Location in patent: Page 72-73 ;
WO 2005/000806 A2
反应条件
n-butyllithium in tetrahydrofuran T=0°C;
参考文献
Brodney, Michael A.; Padwa, Albert
Tetrahedron Letters, 1997 , vol. 38, # 35 p. 6153 - 6156
反应条件
bromine; sodium acetate; acetic acid T=80°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 13, # 19 p. 5278 - 5281
