2,3-二氢苯并[1,4]二恶烷-2-甲腈合成路线 （共 16 条）
反应条件
1: 90 percent / methylate de sodium / 24 h / Ambient temperature 2: 97 percent / chlorure d'ammonium / ethanol / 3.5 h / Heating 3: 87 percent / ethanol / 1.5 h / Heating View Scheme
参考文献
Davrinche; Nguyen-Tri-Xuong; Reynaud; Arnould-Guerin; Tran; Rinjard; Pieri
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 5 p. 397 - 401
反应条件
1: 90 percent / methylate de sodium / 24 h / Ambient temperature 2: 97 percent / chlorure d'ammonium / ethanol / 3.5 h / Heating 3: 73 percent / ethanol / 2 h / Heating View Scheme
参考文献
Davrinche; Nguyen-Tri-Xuong; Reynaud; Arnould-Guerin; Tran; Rinjard; Pieri
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 5 p. 397 - 401
反应条件
1: 90 percent / methylate de sodium / 24 h / Ambient temperature 2: 97 percent / chlorure d'ammonium / ethanol / 3.5 h / Heating 3: 70 percent / ethanol / 3.75 h / Heating View Scheme
参考文献
Davrinche; Nguyen-Tri-Xuong; Reynaud; Arnould-Guerin; Tran; Rinjard; Pieri
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 5 p. 397 - 401
反应条件
sulfuric acid; acetic acid in water T=110°C; 15 h;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: 83 percent / HCl / diethyl ether / 24 h / 0 - 10 °C
2: NH3 / ethanol / 24 h / 0 - 10 °C
View Scheme
参考文献
Davrinche; Nguyen-Tri-Xuong; Reynaud; Arnould-Guerin; Tran; Rinjard; Pieri
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 5 p. 397 - 401
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 7 h / Heating
2: 80 percent / HCl / diethyl ether / 14 h / 0 °C
3: 24 h / Ambient temperature
View Scheme
参考文献
Stillings, Michael R.; Chapleo, Christopher B.; Butler, Richard C. M.; Davis, J. Alfred; England, C. David; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1054 - 1062
