5-甲基-3-苯基异噁唑合成路线 （共 67 条）
反应条件
sodium hydroxide; hydroxylamine hydrochloride in ethanol 2 h; Heating; Yields of byproduct given;
参考文献
Kashima, Choji; Katoh, Akira; Yokota, Yuko; Omote, Yoshimori
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 9 p. 2516 - 2519
反应条件
potassium hydroxide in dimethyl sulfoxide T=100°C; Trofimov reaction; 0.0833333 h;
参考文献
Zaitsev; Schmidt; Mikhaleva; Afonin; Ushakov
Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 6 p. 722 - 729
反应条件
1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 - 5 °C 2.1: indium / tetrahydrofuran; H2O; toluene / 3 h 2.2: tetrahydrofuran; H2O; toluene / 24 h View Scheme
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
1: 66 percent / n-BuLi / tetrahydrofuran / -78 deg C -> r.t. 2: 80 percent / potassium carbonate / methanol / Ambient temperature View Scheme
参考文献
Short; Ziegler Jr.
Tetrahedron Letters, 1993 , vol. 34, # 1 p. 75 - 78
反应条件
in toluene T=110°C; 12 h;
参考文献
Baranski, Andrzej
Polish Journal of Chemistry, 1985 , vol. 59, # 5-6 p. 605 - 612
反应条件
sodium cyanide in tetrahydrofuran; N,N-dimethyl-formamide 12 h; Heating;
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1.1: N-chlorosuccinimide / CHCl3 / 0.33 h / 20 °C 2.1: Et3N / CHCl3 / 12 h / 20 °C 2.2: aq. H2O2 / CHCl3 / 0.33 h / 20 °C View Scheme
参考文献
Sheng, Shou-Ri; Liu, Xiao-Ling; Xu, Qu; Song, Cai-Sheng
Synthesis, 2003 , # 18 p. 2763 - 2764
反应条件
sodium hydroxide in water 1 h; Ambient temperature;
参考文献
Oehler, Elisabeth; Zbiral, Erich
Chemische Berichte, 1980 , vol. 113, # 9 p. 2852 - 2867
参考文献
Moriya, Osamu; Urata, Yoshikiyo; Endo, Takeshi
Journal of the Chemical Society, Chemical Communications, 1991 , # 13 p. 884 - 885
反应条件
1: propargyl bromide With indium in tetrahydrofuran; water; toluene 3 h; 2: BNO in tetrahydrofuran; water; toluene 24 h;
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
