5-甲氧基-1,2,3,4-四氢萘合成路线 (共 24 条)
反应条件
1: 5,8-dihydronaphth-1-ol With potassium carbonate in ethanol 2: dimethyl sulfate in ethanol T=0 - 40°C; 2 h;
参考文献
Briner, Karin; Camp, Anne Marie; Cornell, Alan; Mazanetz, Michael Philip; Rothhaar, Roger Ryan; Victor, Frantz; Williams, Andrew Caerwyn; Zhang, Deyi
Patent: US2008/214520 A1, 2008 ;
Location in patent: Page/Page column 11, 12 ;
反应条件
potassium carbonate in acetone T=45°C; Heating / reflux;
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
Location in patent: Page/Page column 114-115 ;
反应条件
nickel in ethanol T=150°C; P=91200.1 - 114000 Torr;
参考文献
Rao, M. Vishnumurthi; Bhatt, M. Vivekananda
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. <B> 20, # 4 p. 344 - 345
反应条件
Fuller's Earth; 1,2,3,4-tetrahydro-naphthalene; nickel T=50°C; P=36775.4 Torr; Hydrogenation;
参考文献
Musser; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 664,666
反应条件
sodium hydroxide in isopropyl alcohol T=20°C; Birch-type reduction; 3 h; UV-irradiation;
参考文献
Yoshimi, Yasuharu; Ishise, Akihiro; Oda, Hiromu; Moriguchi, Yousuke; Kanezaki, Hiroki; Nakaya, Yukari; Katsuno, Kayoko; Itou, Tatsuya; Inagaki, Sho; Morita, Toshio; Hatanaka, Minoru
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3400 - 3404
反应条件
in ethanol-conc. HCl
参考文献
Rorer Pharmaceutical Corp.
Patent: US4920227 A1, 1990 ;
反应条件
toluene-4-sulfonic acid in chlorobenzene T=132°C; Friedel-Crafts alkylation; 2 h; Title compound not separated from byproducts.;
参考文献
Penick, Mark A.; Mahindaratne, Mathew P. D.; Gutierrez, Robert D.; Smith, Terrill D.; Tiekink, Edward R. T.; Negrete, George R.
Journal of Organic Chemistry, 2008 , vol. 73, # 16 p. 6378 - 6381
反应条件
1: Raney nickel; ethanol / 150 - 190 °C / 73550.8 - 257428 Torr / Hydrogenation 2: aqueous NaOH View Scheme
参考文献
Musser; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 664,666
参考文献
Musser; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 664,666
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Bachmann; Ness
Journal of the American Chemical Society, 1942 , vol. 64, p. 536,538
反应条件
zirconium tetrachloride in dichloromethane 1 h; ultrasonic irradiation, other reagents: TiCl4, ZrBr4, HfCl4, HfBr4;
参考文献
Harrowven, David C.; Dainty, Richard F.
Tetrahedron, 1997 , vol. 53, # 46 p. 15771 - 15786