1-苄基-5-溴-1H-吲哚合成路线 （共 10 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl acetamide T=135°C; 24 h;
参考文献
Dell, Steven; Lozanov, Mario Emilov; Shieh, Wen-Chung
Patent: US2004/59131 A1, 2004 ;
Location in patent: Page 7 ;
反应条件
1: 5-Bromo-1H-indole With potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: benzyl bromide in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
反应条件
1: 5-Bromo-1H-indole With sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 0.666667 h; 2: benzyl bromide in DMF (N,N-dimethyl-formamide) T=0°C; 2 h; 3: With hydrogenchloride; water in DMF (N,N-dimethyl-formamide)
参考文献
Wyeth
Patent: US2004/116504 A1, 2004 ;
Location in patent: Page 8-9 ;
反应条件
potassium hydroxide in N,N-dimethyl-formamide T=0°C; 1 h; Inert atmosphere;
参考文献
Wang, Yi; Yuan; Xing, Chun-Hui; Lu, Long
Tetrahedron Letters, 2014 , vol. 55, # 5 p. 1045 - 1048
反应条件
propylsulfonic acid-functionalized silica in toluene Reflux;
参考文献
Sun, Nan; Hong, Lingfen; Huang, Fang; Ren, Hong; Mo, Weimin; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan
Tetrahedron, 2013 , vol. 69, # 19 p. 3927 - 3933
反应条件
Tsunoda reagent in toluene T=110°C; 15 h;
参考文献
Bombrun, Agnes; Casi, Giulio
Tetrahedron Letters, 2002 , vol. 43, # 12 p. 2187 - 2190
反应条件
in N,N-dimethyl acetamide T=95°C; 96 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 44, # 24 p. 4563 - 4565
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C / |Inert atmosphere 2: propylsulfonic acid-functionalized silica / toluene / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 69, # 19 p. 3927 - 3933
反应条件
sodium t-butanolate; palladium diacetate; tri-tert-butyl phosphine in o-xylene T=120°C; Yield given;
参考文献
Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620
反应条件
1: 80 percent / aq. K2CO3; Pd(OAc)2; Bu4NBr / dioxane / 36 h / 75 °C
2: tetrahydrofuran / 1 h / 20 °C
3: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
4: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
