[5-[7-甲磺酰基-2-(吗啉-4-基)-6,7-二氢-5H-吡咯并[2,3-d]嘧啶-4-基]嘧啶-2-基]胺合成路线 （共 4 条）
反应条件
potassium phosphate; bis-triphenylphosphine-palladium(II) chloride in water; N,N-dimethyl-formamide T=60°C; 2 h; Inert atmosphere;
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: EP2239261 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / N,N-dimethyl-formamide / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1767 - 1772
反应条件
1: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C 2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C 3: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / N,N-dimethyl-formamide / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1767 - 1772
反应条件
1: sodium methylate / methanol / Reflux 2: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C 3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C 4: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / N,N-dimethyl-formamide / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1767 - 1772
