(2-氯吡啶-4-基)甲醇合成路线 （共 17 条）
反应条件
N-bromosuccinmide in ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US5756499 A1, 1998 ;
反应条件
N-bromosuccinmide in ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US5739143 A1, 1998 ;
反应条件
dimethyl sulfoxide; triethylamine in dichloromethane; water
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US5969140 A1, 1999 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane 3 h;
参考文献
US2009/82329 A1, ;
Page/Page column 16 ;
反应条件
sodium hydride in tetrahydrofuran; mineral oil Cooling with ice;
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
Location in patent: Page/Page column 39 ;
反应条件
triethylamine in water; ethyl acetate; pentane
参考文献
Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard
Patent: US2004/77646 A1, 2004 ;
Location in patent: Page 114 ;
反应条件
1: With phosphorus tribromide in dichloromethane
T=0 - 20°C; 3 h; Inert atmosphere;
2: With potassium carbonate in dichloromethane; water
T=0°C; pH=7;
参考文献
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY; TSANTRIZOS, Youla, S.; DE SCHUTTER, Joris, Wim; LIN, Yih-Shyan
Patent: WO2011/147038 A1, 2011 ;
Location in patent: Page/Page column 43-44 ;
