in hydrogenchloride; water

1.1: acetic anhydride / 1 h / 130 °C 1.2: 1 h 2.1: sodium hydride / tetrahydrofuran / 1.5 h / |Inert atmosphere; |Reflux 3.1: acetic acid; hydrogenchloride / 7.5 h / |Reflux View Scheme

1: sodium hydride / tetrahydrofuran / 1.5 h / |Inert atmosphere; |Reflux 2: acetic acid; hydrogenchloride / 7.5 h / |Reflux View Scheme

1.1: trifluoroacetic acid; hydrogenchloride / water / 26 h / |Reflux 2.1: thionyl chloride / 2.5 h / 85 °C 3.1: 2,2'-biquinoline; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 4.1: acetic anhydride / 1 h / 130 °C 4.2: 1 h 5.1: sodium hydride / tetrahydrofuran / 1.5 h / |Inert atmosphere; |Reflux 6.1: acetic acid; hydrogenchloride / 7.5 h / |Reflux View Scheme

1.1: thionyl chloride / 2.5 h / 85 °C 2.1: 2,2'-biquinoline; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 3.1: acetic anhydride / 1 h / 130 °C 3.2: 1 h 4.1: sodium hydride / tetrahydrofuran / 1.5 h / |Inert atmosphere; |Reflux 5.1: acetic acid; hydrogenchloride / 7.5 h / |Reflux View Scheme

1.1: 2,2'-biquinoline; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 2.1: acetic anhydride / 1 h / 130 °C 2.2: 1 h 3.1: sodium hydride / tetrahydrofuran / 1.5 h / |Inert atmosphere; |Reflux 4.1: acetic acid; hydrogenchloride / 7.5 h / |Reflux View Scheme