1-苄基-1H-咪唑-2-甲醛合成路线 （共 16 条）
反应条件
potassium carbonate in acetonitrile T=0 - 40°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 200-201 ;
反应条件
1: 1-benzyl-imidazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
Zhou, Yirong; Gong, Yuefa
European Journal of Organic Chemistry, 2011 , # 30 p. 6092 - 6099
反应条件
n-butyllithium in N,N-dimethyl-formamide
参考文献
Linke, Siegfried; Kurz, Juergen; Lipinski, Dietmar; Gau, Wolfgang
Liebigs Annalen der Chemie, 1980 , # 4 p. 542 - 556
反应条件
1: 1H-imidazole With potassium hydroxide in acetone 2 h; 2: benzyl bromide in acetone
参考文献
Kleyi, Phumelele; Walmsley, Ryan S.; Gundhla, Isaac Z.; Walmsley, Tara A.; Jauka, Tembisa I.; Dames, Joanna; Walker, Roderick B.; Torto, Nelson; Tshentu, Zenixole R.
South African Journal of Chemistry, 2012 , vol. 65, p. 231 - 238
反应条件
1.1: potassium carbonate / tetrahydrofuran / 0.17 h / 20 °C 1.2: Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 - 20 °C View Scheme
参考文献
Zhou, Yirong; Gong, Yuefa
European Journal of Organic Chemistry, 2011 , # 30 p. 6092 - 6099
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h 1.2: 2 h / 50 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: 2 h / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Jiang, Nan; Zhai, Xin; Zhao, Yanfang; Liu, Yajing; Qi, Baohui; Tao, Haiyan; Gong, Ping
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 534 - 541
反应条件
selenium(IV) oxide in 1,4-dioxane
参考文献
Odzak, Renata; Skocibusic, Mirjana; Maravic, Ana
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 23 p. 7499 - 7506
反应条件
in ethanol 7 h; Heating;
参考文献
Iradyan, M. A.; Iradyan, N. S.; Stepanyan, G. M.; Arsenyan, F. G.; Garibdzhanyan, B. T.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 2 p. 92 - 96
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 2 p. 22 - 24
反应条件
p-toluenesulfonic acid monohydrate; sodium carbonate in ethylene glycol; toluene
参考文献
Sterling Winthrop Inc.
Patent: US5569655 A1, 1996 ;
反应条件
toluene-4-sulfonic acid Heating;
参考文献
Kumar, Virendra; Carbateas, Phil M.; Dority, John A.; Earley, William G.; Mallamo, John P.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1826 - 1830
