1-(2-苯基-1，3-噻唑-4-基）乙酮合成路线 （共 10 条）
反应条件
in tetrahydrofuran; anhydrous butyl ether T=0°C; 0.533333 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00219 ;
反应条件
hydrogenchloride; formaldehyd T=100°C;
参考文献
Sarodnick; Kempter
Pharmazie, 1983 , vol. 38, # 12 p. 829 - 832
反应条件
in chloroform Ambient temperature;
参考文献
Shafiee, A.; Anaraki, M.; Bazzaz, A.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 861 - 864
反应条件
sulfuric acid; sodium nitrite in ethanol T=45 - 50°C; 5 h;
参考文献
Chemische Berichte, , vol. 97, p. 1915 - 1920
反应条件
1: acetone 2: aq. H2SO4, NaNO2 / ethanol / 5 h / 45 - 50 °C View Scheme
参考文献
Chemische Berichte, , vol. 97, p. 1915 - 1920
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 22 °C 2: triethylamine / dichloromethane / 1 h / 20 °C / |Cooling with ice 3: tetrahydrofuran; anhydrous butyl ether / 0.53 h / 0 °C View Scheme
反应条件
1: sodium hydroxide; water / methanol / 1.03 h / 20 °C 2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 22 °C 3: triethylamine / dichloromethane / 1 h / 20 °C / |Cooling with ice 4: tetrahydrofuran; anhydrous butyl ether / 0.53 h / 0 °C View Scheme
反应条件
1: triethylamine / dichloromethane / 1 h / 20 °C / |Cooling with ice 2: tetrahydrofuran; anhydrous butyl ether / 0.53 h / 0 °C View Scheme
参考文献
Simiti,I.; Farkas,M.
Bulletin de la Societe Chimique de France, 1968 , p. 3862 - 3866
反应条件
sodium hydroxide; hydroxylamine hydrochloride in ethanol
参考文献
Silberg,A.; Benkoe,A.
Chemische Berichte, 1964 , vol. 97, p. 1915 - 1920
