sodium methylate in methanol 48 h; Heating;

1: 81 percent / dimethylformamide / 2 h / 90 °C 2: methylhydrazine / ethanol / 2 h / Heating 3: EtONa / ethanol / 1 h / Heating View Scheme

1: 97 percent / 0.65 M HCl / Ambient temperature 2: 91 percent / DCC, pyridine, DMAP / CH2Cl2 / 64 h / Ambient temperature 3: 75 percent / LiBH4, LiEt3BH / tetrahydrofuran / Ambient temperature 4: 66 percent / DAST / CH2Cl2 / 60 h / Ambient temperature 5: phosphate buffer / Ambient temperature; immobilized penicillin-G amidase View Scheme

1: With lithium aluminium tetrahydride in tetrahydrofuran 16 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran T=20°C; 1 h;