N-甲氧基-n-甲基异烟酰胺合成路线 （共 10 条）
反应条件
1: isonicotinic acid With 1,1'-carbonyldiimidazole in dichloromethane T=20°C; 2.75 h; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=20°C; 3: With sodium hydroxide in dichloromethane; water T=20°C; 0.0833333 h; Product distribution / selectivity;
参考文献
Aventis Pharmaceuticals, Inc.; Hoechst Marion Roussel Deutschland GmbH
Patent: EP1734037 A2, 2006 ;
Location in patent: Page/Page column 17; 62 ;
反应条件
triethylamine; HATU in dichloromethane T=20°C; 12 h; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.
Patent: WO2009/158393 A1, 2009 ;
Location in patent: Page/Page column 117 ;
参考文献
Aventis Pharmaceuticals Inc.; Aventis Pharma Deutschland GmbH
Patent: US2005/261341 A1, 2005 ;
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With dimethylaluminum chloride in hexane; dichloromethane T=0°C; 1.5 h; 2: 4-pyridinecarboxylic acid methyl ester in hexane; dichloromethane T=20°C; 8 h;
参考文献
Stockmann, Vegar; Kaspersen, Svein Jacob; Nicolaisen, Alexander; Fiksdahl, Anne
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 613 - 620
反应条件
1: dichloromethane / 2.5 h / 20 °C 2: dichloromethane / 24 h View Scheme
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
反应条件
in dichloromethane 24 h;
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
反应条件
1: 4-bromothiophene-3-carboxylic acid With lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane T=-78°C; 1 h; 2: N-methoxy-N-methyl-4-pyridinecarboxamide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane T=-78 - 20°C; 1 h;
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; OCHSE, Michael; DRESCHER, Karla; TURNER, Sean; BEHL, Berthold; LAPLANCHE, Loic; DINGES, Jürgen; JAKOB, Clarissa; BLACK, Lawrence
Patent: US2013/116233 A1, 2013 ;
Location in patent: Paragraph 1020; 1021 ;
反应条件
methyl-magnesium iodide in tetrahydrofuran T=0 - 5°C; 2 h;
参考文献
US2005/245517 A1, ;
Page/Page column 12 ;
反应条件
in tetrahydrofuran
T=-78°C; 2 h;
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian
Patent: WO2011/38204 A1, 2011 ;
Location in patent: Page/Page column 146-147 ;
WO 2011/038204 A1
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
T=20 - 100°C; Inert atmosphere;
参考文献
Bommegowda, Yadaganahalli K.; Lingaraju, Gejjalagere S.; Thamas, Saji; Vinay Kumar, Koravangala S.; Pradeepa Kumara, Challanayakanahally S.; Rangappa, Kanchugarakoppal S.; Sadashiva, Marilinganadoddi P.
Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2693 - 2695
