Cai, Sui Xiong; Zhang, Han-Zhong; Drewe, John A.; Reddy, P. Sanjeeva; Kasibhatla, Shailaja; Kuemmerle, Jared Daniel; Ollis, Kristin P.
Patent: US2003/45546 A1, 2003 ;
US 20030045546 A1
1.1: n-butyllithium / hexane; toluene / 0.58 h / -78 °C 1.2: 1 h / -78 °C 2.1: sodium tetrahydroborate / methanol / 0.5 h / -78 - 20 °C View Scheme
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
Cai, Sui Xiong; Zhang, Han-Zhong; Drewe, John A.; Reddy, P. Sanjeeva; Kasibhatla, Shailaja; Kuemmerle, Jared Daniel; Ollis, Kristin P.
Patent: US2003/45546 A1, 2003 ;
US 20030045546 A1
1: 2-iodo-5-(trifluoromethyl)pyridine With n-butyllithium in hexane; toluene T=-78°C; 0.583333 h; 2: N,N-dimethyl-formamide in hexane; toluene T=-78°C; 1 h;
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
1.1: n-butyllithium / hexane; toluene / 0.58 h / -78 °C 1.2: 1 h / -78 °C 2.1: sodium tetrahydroborate / methanol / 0.5 h / -78 - 20 °C 3.1: 2,4,6-trichloro-1,3,5-triazine / dichloromethane; N,N-dimethyl-formamide / 60 h / 20 °C / Reflux View Scheme
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
