3-[2-[(E)-[3-(3-甲氧基-3-氧代-丙基)-4-甲基-5-[(E)-(3-甲基-5-氧代-4-乙烯基-吡咯-2-亚基)甲基]吡咯-2-亚基]甲基]-4-甲基-5-[(E)-(4-甲基-5-氧代-3-乙烯基-吡咯-2-亚基)甲基]-1H-吡咯-3-基]丙酸甲酯合成路线 （共 26 条）
反应条件
sodium hydroxide in pyridine 2.5 h; Heating;
参考文献
Smith, Kevin M.; Pandey, Ravindra K.
Tetrahedron, 1984 , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 95 percent / lead tetra-acetate / acetic acid / Ambient temperature 2: 81 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 3: 92 percent / H2, triethylamine / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 4: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 5: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 6: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 82 percent / lead tetra-acetate / acetic acid 2: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 3: 98 percent / triethylamine, H2 / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 4: 1) p-toluene sulfonic acid hydrate; 2) calcium carbonate, phosphoryl chloride / 1) dichloromethane, methanol, 40 min, room temperature; 2) 1.5h, room temperature 5: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 6: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 7: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 2: 98 percent / triethylamine, H2 / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 3: 1) p-toluene sulfonic acid hydrate; 2) calcium carbonate, phosphoryl chloride / 1) dichloromethane, methanol, 40 min, room temperature; 2) 1.5h, room temperature 4: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 5: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 6: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 2: 98 percent / triethylamine, H2 / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 3: 1) p-toluene sulfonic acid hydrate; 2) calcium carbonate, phosphoryl chloride / 1) dichloromethane, methanol, 40 min, room temperature; 2) 1.5h, room temperature 4: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 5: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 6: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 81 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 2: 92 percent / H2, triethylamine / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 3: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 4: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 5: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 98 percent / triethylamine, H2 / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 2: 1) p-toluene sulfonic acid hydrate; 2) calcium carbonate, phosphoryl chloride / 1) dichloromethane, methanol, 40 min, room temperature; 2) 1.5h, room temperature 3: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 4: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 5: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 92 percent / H2, triethylamine / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 2: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 3: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 4: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 90 percent / zinc dust, acetic acid / 3 h / Heating 2: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 3: 98 percent / triethylamine, H2 / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 4: 1) p-toluene sulfonic acid hydrate; 2) calcium carbonate, phosphoryl chloride / 1) dichloromethane, methanol, 40 min, room temperature; 2) 1.5h, room temperature 5: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 6: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 7: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
反应条件
1: 80 percent / sodium bicarbonate, iodine, potassium iodide / methanol; H2O / 60 °C 2: 90 percent / zinc dust, acetic acid / 3 h / Heating 3: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C 4: 98 percent / triethylamine, H2 / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 5: 1) p-toluene sulfonic acid hydrate; 2) calcium carbonate, phosphoryl chloride / 1) dichloromethane, methanol, 40 min, room temperature; 2) 1.5h, room temperature 6: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 7: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 8: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 40, # 10 p. 1749 - 1754
