N-(N-乙酰基-3-苯基-L-丙氨酰)-3-苯基-L-丙氨酸合成路线 （共 10 条）
反应条件
hydrogen; Rh[(+)-DIOP]Cl in methanol; benzene P=760 Torr; Ambient temperaturefurther hydrogenation catalysts; Yield given. Yields of byproduct given;
参考文献
Ikeda; Yamagishi; Yamaguchi; Hida
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 11 p. 3508 - 3512
反应条件
hydrogen; Rh(I)-chiral diphosphinite in ethanol T=20°C; 45 h; other chiral diphosphinite, other time; Title compound not separated from byproducts;
参考文献
Yatagai; Yamagishi; Hida
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 3 p. 823 - 826
反应条件
hydrogen; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; diphosphinite 5 in ethanol T=20°C; P=760 Torr; 0.25 h;
参考文献
Yatagai, Masanobu; Zama, Masanobu; Yamagishi, Takamichi; Hida, Mitsuhiko
Chemistry Letters, 1983 , p. 1203 - 1206
反应条件
sodium hydroxide; chymotrypsin in methanol T=25 - 30°C; saponification; pH=7.2 - 7.6; 16 h;
参考文献
Kotlova; Timokhina; Chestukhina; Stepanov
Russian Journal of Bioorganic Chemistry, 1999 , vol. 25, # 9 p. 579 - 583
反应条件
1: aq. NaOH; thermolysin / 24 h / 37 °C / pH 6.3 2: aq. NaOH; chymotrypsin / methanol / 16 h / 25 - 30 °C / pH 7.2 - 7.6 View Scheme
参考文献
Smith; Spackman
Journal of Biological Chemistry, 1955 , vol. 212, p. 271,291
反应条件
1: 3 h / 0 - 4 °C 2: aq. NaOH; thermolysin / 24 h / 37 °C / pH 6.3 3: aq. NaOH; chymotrypsin / methanol / 16 h / 25 - 30 °C / pH 7.2 - 7.6 View Scheme
参考文献
Kotlova; Timokhina; Chestukhina; Stepanov
Russian Journal of Bioorganic Chemistry, 1999 , vol. 25, # 9 p. 579 - 583
反应条件
1: pyridine / 1-methyl-pyrrolidin-2-one / 20 °C / pH 7 2: 1-methyl-pyrrolidin-2-one / 48 h / 20 °C / pH 7 View Scheme
参考文献
Chen, Wenteng; Shao, Jiaan; Hu, Miao; Yu, Wanwan; Giulianotti, Marc A.; Houghten, Richard A.; Yu, Yongping
Chemical Science, 2013 , vol. 4, # 3 p. 970 - 976
反应条件
1: ethanol; N2H4+H2O 2: NaNO2; aqueous acetic acid; aqueous HCl / Behandeln des Reaktionsprodukts mit L-Phenylalanin-aethylester in Aethylacetat und Aether 3: acetone; aqueous NaOH View Scheme
参考文献
Smith; Spackman
Journal of Biological Chemistry, 1955 , vol. 212, p. 271,291
反应条件
1: NaNO2; aqueous acetic acid; aqueous HCl / Behandeln des Reaktionsprodukts mit L-Phenylalanin-aethylester in Aethylacetat und Aether 2: acetone; aqueous NaOH View Scheme
参考文献
Smith; Spackman
Journal of Biological Chemistry, 1955 , vol. 212, p. 271,291
反应条件
in 1-methyl-pyrrolidin-2-one T=20°C; pH=7; 48 h;
参考文献
Chen, Wenteng; Shao, Jiaan; Hu, Miao; Yu, Wanwan; Giulianotti, Marc A.; Houghten, Richard A.; Yu, Yongping
Chemical Science, 2013 , vol. 4, # 3 p. 970 - 976
