5-溴-1-甲基-1H-咪唑合成路线 （共 12 条）
反应条件
in methanol T=-25°C; 120 h;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 97, # 8-9 p. 573 - 598
反应条件
N-bromosuccinmide in chloroform 2 h; Heating;
参考文献
Polish Journal of Chemistry, , vol. 55, # 7/8 p. 1659 - 1665
反应条件
T=235 - 245°C; P=28 Torr;
参考文献
Heterocycles, , vol. 33, # 1 p. 21 - 26
反应条件
n-butyllithium in diethyl ether; hexane T=-70°C; 0.666667 h; Yield given. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 735 - 739
反应条件
in N,N-dimethyl-formamide 6 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 9 p. 1784 - 1790
反应条件
Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1139 - 1145
参考文献
Journal of the Chemical Society, , vol. 125, p. 1569
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene Heating / reflux;
参考文献
Methylgene, Inc.
Patent: US2007/4675 A1, 2007 ;
Location in patent: Page/Page column 63 ;
US 20070004675 A1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate in N,N-dimethyl-formamide T=100°C; Suzuki coupling; 3 h; Microwave irradiation;
参考文献
Garton, Neil; Bailey, Nick; Bamford, Mark; Demont, Emmanuel; Farre-Gutierrez, Irene; Hutley, Gail; Bravi, Gianpaolo; Pickering, Paula
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1049 - 1054
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; diisobutylaluminium hydride in 1,4-dioxane
T=100°C; 2.5 h;
参考文献
Gibson, Christoph; Schnatbaum, Karsten; Pfeifer, Jochen R.; Locardi, Elsa; Paschke, Matthias; Reimer, Ulf; Richter, Uwe; Scharn, Dirk; Faussner, Alexander; Tradler, Thomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4370 - 4379
