反应条件
1.1: diethyl ether / 12 h / 20 °C 2.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 0.33 h / -10 °C 2.2: 3 h / -10 - 20 °C 3.1: sodium hydrogencarbonate / ethyl acetate / 18 h / 0 - 20 °C 4.1: iron; acetic acid / 2 h / 80 °C 5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C 6.1: hydrogenchloride / ethanol; water / 18 h / Reflux 7.1: O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C View Scheme
参考文献
Chen, Shaoqing; Bartkovitz, David; Cai, Jianping; Chen, Yi; Chen, Zhi; Chu, Xin-Jie; Le, Kang; Le, Nam T.; Luk, Kin-Chun; Mischke, Steve; Naderi-Oboodi, Goli; Boylan, John F.; Nevins, Tom; Qing, Weiguo; Chen, Yingsi; Wovkulich, Peter M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1247 - 1250
