氮杂环丁烷-3-甲酸甲酯盐酸盐合成路线 （共 5 条）
反应条件
hydrogenchloride; hydrogen; palladium(II) hydroxide/carbon in methanol; ethyl acetate T=20°C; P=3000.3 Torr; 11 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1889836 A1, 2008 ;
Location in patent: Page/Page column 80 ;
反应条件
thionyl chloride T=5 - 65°C;
参考文献
PFIZER INC.; BROWN, Matthew, Frank; MITTON-FRY, Mark. J.; HAN, Seungil; LALL, Manjinder; PLUMMER, Mark, Stephen; RISLEY, Hud, Lawrence; SHANMUGASUNDARAM, Veerabahu; STARR, Jeremy, T.
Patent: WO2012/73138 A1, 2012 ;
Location in patent: Page/Page column 55-56 ;
WO 2012/073138 A1
反应条件
chloro-trimethyl-silane in methanol
参考文献
Pfizer Products Inc.
Patent: EP978279 A1, 2000 ;
反应条件
1: azetidine-3-carboxylic acid methyl ester hydrochloride; di-tert-butyl dicarbonate With sodium hydrogencarbonate in tetrahydrofuran; water T=0 - 20°C; 20 h; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in tetrahydrofuran; water; ethyl acetate T=0 - 20°C; 60.5 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2008/214815 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
SANOFI-AVENTIS
Patent: US2011/183960 A1, 2011 ;
Location in patent: Page/Page column 27 ;
