2-[(1E)-2-(2-溴苯基)乙烯基]-4-氯-苯酚-1-乙酸酯合成路线 (共 3 条)
反应条件
1: (2-bromobenzyl)phosphonic acid diethyl ester; 5-chloro-2-hydroxybenzaldehyde With potassium tert-butylate in tetrahydrofuran T=-10 - 20°C; Wittig-Horner reaction; 1 h; 2: acetic anhydride in tetrahydrofuran T=20°C; 1 h;
参考文献
N.V. ORGANON
Patent: WO2008/3460 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
1: (2-bromobenzyl)phosphonic acid diethyl ester; 5-chloro-2-hydroxybenzaldehyde With potassium tert-butylate in tetrahydrofuran; toluene T=-10 - 0°C; Wittig-Horner Reaction; 2: acetic anhydride in tetrahydrofuran; toluene T=-5 - 20°C;
参考文献
N.V. ORGANON
Patent: WO2009/87058 A1, 2009 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 4-chloro-2-hydroxy-benzaldehyde; (2-bromobenzyl)phosphonic acid diethyl ester With potassium tert-butylate in tetrahydrofuran T=-10 - 5°C; Wittig Reaction; 1 h; 2: acetic anhydride in tetrahydrofuran T=-5 - 20°C; 1 h;
参考文献
N.V. Organon
Patent: US2008/9619 A1, 2008 ;
Location in patent: Page/Page column 10; 11 ;